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Overview
Dolutegravir (GSK 1349572) is a potent integrase strand transfer inhibitor (INSTI). Its core synthesis involves advanced heterocyclic coupling. Molecular formula: C13H16N4O3; CAS No: 109738-16-9.
Application
- Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) for antiretroviral combination therapies.
- HIV Treatment: Used in regimens to suppress viral replication in treatment-naïve and experienced patients.
- Research & Development: Standard reference compound for virology studies and efficacy assays.
Precautions
Strictly monitor for hypersensitivity reactions and potential drug-drug interactions. Store API in sealed containers at controlled room temperature, protected from moisture and light to maintain stability.