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Overview
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor peptide synthesized via enzymatic processing of preproendothelin. Molecular Formula: C40H58N12O13S2; CAS No.: 139478-63-6.
Application
- Pharmaceutical R&D: Used as a reference standard for developing endothelin receptor antagonists in cardiovascular research.
- Bioassay Services: Employed in high-throughput screening to evaluate vascular reactivity and smooth muscle contraction mechanisms.
- Academic Research: Utilized to investigate pathophysiological roles in hypertension, pulmonary arterial hypertension, and renal fibrosis.
Precautions
- Strictly for laboratory research use only; not approved for clinical therapeutic application.
- Store at -20°C under inert atmosphere to prevent oxidation and degradation.
- Handle with appropriate PPE due to potential allergenic properties of peptide derivatives.