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Overview
Etrasimod Arginine is the arginine salt form of etrasimod, a next-generation S1P receptor modulator. Synthesized via acid-base reaction between etrasimod free base and L-arginine to enhance aqueous solubility. Molecular formula: C20H27N5O4; CAS No.: 2647893-39-2.
Application
- Pharmaceutical Manufacturing: API production for oral tablets targeting autoimmune disorders like ulcerative colitis.
- Formulation Development: Used in solid dosage forms requiring improved dissolution profiles compared to free base.
- Clinical Trials: Serves as investigational material for Phase II/III studies evaluating efficacy and safety in relapsing-remitting multiple sclerosis.
Precautions
Requires strict temperature control (2–8°C) during storage to prevent hydrolysis. Clinical use restricted by contraindications including active infections, recent myocardial infarction, and pregnancy. Handling mandates PPE due to potential respiratory sensitization.