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Overview
Evolocumab is a recombinant human monoclonal antibody targeting PCSK9. Produced via mammalian cell culture, its molecular formula is C7561H11804N2046O2326S50 (CAS: 1297175-28-0).
Application
- Lipid Management: Adjunct to diet for hypercholesterolemia.
- Cardiovascular Risk Reduction: Prevents major adverse cardiac events in high-risk patients.
- Homozygous FH Treatment: Lowers LDL-C in genetic disorders unresponsive to statins.
Precautions
Contraindicated in hypersensitivity. Requires refrigeration at 2°C–8°C; do not freeze or shake. Monitor for injection site reactions and monitor liver enzymes periodically.