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Overview
Exemestane is a potent steroidal aromatase inhibitor synthesized via enzymatic or chemical modification of androstenedione. It functions by irreversibly binding to the enzyme, blocking estrogen synthesis in postmenopausal women. Its molecular formula is C20H24O2 with CAS number 107868-30-4.
Application
- Oncology Manufacturing: Active pharmaceutical ingredient (API) for breast cancer treatment.
- Hormone Therapy: Used in adjuvant therapy for hormone receptor-positive tumors.
- Research & Development: Standard compound for endocrinology studies on estrogen pathways.
Precautions
Contraindicated in premenopausal women and pregnant patients. Store API in cool, dry conditions below 25°C away from light. Ensure strict PPE usage during handling to prevent dermal absorption and respiratory irritation.