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Overview
Filgotinib (GLPG0634) is an oral selective JAK1 inhibitor developed for autoimmune disorders. Its core synthesis involves advanced heterocyclic chemistry. The molecular formula is C23H25FN4O with CAS number 1798683-06-5.
Application
- Rheumatology: Treatment of moderate-to-severe rheumatoid arthritis.
- Gastroenterology: Clinical trials for ulcerative colitis management.
- Dermatology: Investigation into psoriasis therapeutic pathways.
Precautions
Strictly monitor for hepatotoxicity and infection risks during therapy. Store as a solid API in sealed containers at 2–8°C away from moisture to maintain stability.