Category:
Chiral Intermediates
CAS NO:
74853-08-0
Standard:
In-house Standards,
/
The first intermediate of posaconazole, typically N-(1H-1,2,4-triazol-1-ylmethyl)-2,4-dichlorobenzamide (CAS 167850-96-8), is a key chiral building block synthesized via acylation. It serves as the foundational scaffold for constructing the triazole core in the multi-step manufacturing of the broad-spectrum antifungal agent.
Store in a cool, dry place under inert atmosphere to prevent hydrolysis. Personnel must wear appropriate PPE including respirators and chemical-resistant gloves due to potential respiratory sensitization. Avoid direct contact with skin and eyes during handling.