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Overview
FMOC-TRP(1-ME)-OH (CAS: 156784-29-9) is a protected Fmoc-L-tryptophan derivative featuring a methyl group on the indole nitrogen. This reagent is synthesized via selective methylation followed by Fmoc protection, serving as a critical building block for peptide synthesis.
Application
- Pharmaceutical Manufacturing: Used in solid-phase peptide synthesis (SPPS) to construct complex therapeutic peptides.
- Peptide Research: Essential for modifying tryptophan residues in research-grade oligopeptides.
- Process Chemistry: Applied in the development of novel drug candidates requiring specific side-chain modifications.
Precautions
Store under inert atmosphere at -20°C to prevent degradation. Avoid skin contact and inhalation; use appropriate PPE. Not intended for direct clinical administration without formulation into approved pharmaceutical products.