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Overview
Fosaprepitant is a prodrug of aprepitant, an neurokinin-1 (NK1) receptor antagonist. It is manufactured via phosphoramidate esterification to enhance water solubility for intravenous administration. The chemical formula is C25H24ClN4O6P and CAS number is 209877-70-3.
Application
- Oncology Care: Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV).
- Perioperative Medicine: Adjunct therapy in combination with 5-HT3 antagonists and corticosteroids.
- Hospital Pharmacy: Large-scale IV infusion protocols requiring rapid dissolution and stability.
Precautions
Contraindicated in patients receiving drugs metabolized by CYP3A4 due to strong induction risks. Requires strict temperature control during storage to prevent hydrolysis. Medical personnel must handle powder with appropriate PPE to avoid inhalation exposure.