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Overview
Fosaprepitant dimeglumine is a water-soluble prodrug of aprepitant, utilized for preventing chemotherapy-induced nausea and vomiting. Synthesized via acylation of aprepitant with dimeglumine, it features the molecular formula C29H34ClFN4O5 and CAS number 265121-04-8.
Application
- Oncology: Prophylaxis of acute and delayed emesis in patients receiving highly emetogenic chemotherapy.
- Hospital Pharmacy: Intravenous administration as part of multi-agent antiemetic regimens.
Precautions
Contraindicated in patients taking p-glycoprotein substrates like oral midazolam or triazolam. Store in sealed containers at controlled room temperature (20°C to 25°C) to maintain stability and prevent hydrolysis.