Gadobutrol is a kind of contrast media for MRI.
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Overview
Gadobutrol is a non-ionic macrocyclic Gd-based contrast agent used primarily in magnetic resonance imaging. Synthesized via chelation of gadolinium with the macrocyclic ligand DO3A-buta, it ensures high thermodynamic stability. Its chemical formula is C18H26GdN5O9, and the CAS number is 101570-77-2.
Application
- Diagnostics: Enhances visualization of CNS tumors, multiple sclerosis lesions, and vascular anomalies.
- Cardiovascular Imaging: Facilitates detailed assessment of myocardial perfusion and viability.
- Research: Utilized in preclinical studies for blood-brain barrier permeability analysis.
Precautions
Contraindicated in patients with severe renal impairment due to nephrogenic systemic fibrosis risks. Must be stored below 25°C in original packaging. Strict aseptic techniques are required during parenteral administration to prevent contamination.