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Overview
Gadodiamide is a non-ionic Gadolinium-based contrast agent (GBCA) used primarily in magnetic resonance imaging. Its core synthesis involves chelating gadolinium ions with diethylenetriaminepentaacetic acid derivatives to ensure stability and safety. The chemical formula is C19H28GdN4O10, and its CAS number is 101122-73-4.
Application
- Medical Imaging: Enhances visualization of central nervous system tumors, vascular malformations, and inflammatory lesions during MRI scans.
- Diagnostics: Facilitates differentiation between normal and pathological tissues in neurology and oncology departments.
Precautions
Strictly contraindicated for patients with severe renal impairment due to risks of nephrogenic systemic fibrosis. Requires storage in controlled temperature environments away from direct sunlight to maintain chemical stability and efficacy.