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Overview
Gadoteridol is a non-ionic gadolinium-based contrast agent (GBCA) used for magnetic resonance imaging. Synthesized via chelation of Gd³⁺ with the macrocyclic ligand protonated hydroxypropyl-diglycolamide, it ensures high kinetic stability. Its molecular formula is C₁₄H₂₅GdN₃O₉ and CAS number is 148956-70-9.
Application
- Diagnostic Imaging: Enhances visualization of CNS structures in MRI scans.
- Neurology: Detects blood-brain barrier disruptions in tumors or inflammation.
- Oncology: Assists in tumor delineation and treatment response monitoring.
Precautions
Contraindicated in patients with severe renal impairment due to nephrogenic systemic fibrosis risk. Avoid use during pregnancy unless essential. Store at controlled room temperature away from direct light to maintain solution integrity.