Category:
Active Pharmaceutical Ingredients
CAS NO:
1416992-39-6
Standard:
EP,
GC376 is a 3CLpro (3C-like protease) inhibitor, and the IC50 value of 3CLpro for PEDV is about 1.11 μM. GC376 is active against 3CLpro of several coronaviruses, including SARS-CoV.
GC376, chemically known as Maraviroc, is a selective CCR5 antagonist developed for HIV-1 treatment. Its core synthesis involves complex heterocyclic coupling reactions. Molecular formula: C29H40N8O4S; CAS No: 367340-58-5.
Strictly contraindicated for X4-tropic or dual/mixed tropism infections. Requires storage in sealed containers at 2-8°C. Personnel must wear appropriate PPE during handling due to potential toxicity.