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Overview
Gemcitabine Hydrochloride is a nucleoside analog antineoplastic agent synthesized via enzymatic fluorination. Its molecular formula is C9H10ClFN2O4 and CAS number is 122111-03-3.
Application
- Oncology Manufacturing: Bulk production for injectable formulations targeting pancreatic, lung, and breast cancers.
- Clinical Research: Supply for Phase I-III trials investigating combination therapies with platinum agents.
- Pharmaceutical Formulation: Active Pharmaceutical Ingredient (API) for hospital compounding units.
Precautions
Strictly contraindicated in patients with severe renal impairment. Requires storage below 25°C in dry, light-resistant conditions. Personnel must utilize PPE to prevent dermal exposure during handling.