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Overview
Gimeracil is a pyrimidine analog used as a key intermediate in the synthesis of 5-fluorouracil. It acts as a dihydropyrimidine dehydrogenase (DPD) inhibitor to enhance therapeutic efficacy. The compound features the molecular formula C10H7N2O4F and carries CAS No. 89269-73-6.
Application
- Pharmaceutical Manufacturing: Primary component in fixed-dose combination drugs like Capecitabine.
- Oncology Therapy: Synergistic agent with fluoropyrimidines for colorectal and gastric cancers.
- R&D Sector: Standard reagent for metabolic pathway studies involving DPD inhibition.
Precautions
- Strictly regulated for clinical use only; not for industrial non-pharma applications.
- Requires storage in cool, dry conditions below 25°C away from light.
- Handle with PPE due to potential mutagenic properties and toxicity.