Category:
Active Pharmaceutical Ingredients
CAS NO:
103766-25-2
Standard:
In-house Standards,
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Gimeracil (TS-1) is a pyrimidine antimetabolite serving as the primary component of the fixed-dose combination drug S-1. It acts by inhibiting thymidine phosphorylase, thereby enhancing the cytotoxicity and tumor concentration of 5-fluorouracil (5-FU). Molecular Formula: C6H4N2O3; CAS No.: 98779-90-1. Synthesis typically involves condensation reactions of uracil derivatives.
Strictly contraindicated in patients with severe hepatic impairment or known hypersensitivity. Requires storage in cool, dry environments away from light. Clinical use mandates monitoring for hematological toxicity and gastrointestinal adverse events under professional supervision.