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*The following content is generated by AI and is for reference only.
Overview
Granisetron Hydrochloride is a potent 5-HT3 receptor antagonist used primarily for antiemetic therapy. Synthesized via controlled amidation, its molecular formula is C20H26ClN3O·HCl (CAS: 107868-39-3).
Application
- Oncology: Prevention of chemotherapy-induced nausea and vomiting.
- Surgery: Management of postoperative nausea and vomiting (PONV).
- Radiation Therapy: Control of acute emesis in radiation-treated patients.
Precautions
Contraindicated in patients with known hypersensitivity to granisetron or benzyl alcohol. Store at controlled room temperature (20-25°C) in a dry environment away from direct light to maintain stability.