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Overview
Grazoprevir is a potent, selective HCV NS3/4A protease inhibitor used in direct-acting antiviral therapies. Its core synthesis involves complex chiral coupling and macrocyclization. The compound is defined by the molecular formula C29H30ClN5O6 and CAS No. 1279988-10-9.
Application
- Manufacturing of fixed-dose combination tablets for Hepatitis C treatment.
- API production for chronic HCV genotype 1 infection protocols.
- R&D formulation of novel antiviral regimens targeting viral resistance.
Precautions
Strictly contraindicated in patients with severe hepatic impairment or concomitant use of strong CYP3A inducers. Store API under controlled conditions at 25°C to maintain chemical stability and potency.