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Overview
Hoe 140, commercially known as Icatibant, is a potent, selective bradykinin B2 receptor antagonist. Its core synthesis involves complex peptide modification to ensure high stability and bioavailability. The molecular formula is C69H100N22O18S with CAS No. 157833-52-4.
Application
- Pharmaceutical manufacturing for Hereditary Angioedema (HAE) prophylaxis and acute attack treatment.
- Research chemical supply for studying kinin-kallikrein pathways in inflammatory models.
Precautions
Strictly contraindicated for patients with hypersensitivity to the active substance or excipients. Store at controlled room temperature (20°C–25°C) in original sealed containers to prevent hydrolysis. Maintain rigorous safety protocols during handling due to potential sensitization risks.