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Overview
Imatinib mesylate (CAS 220195-86-7) is a targeted kinase inhibitor with molecular formula C15H16N4O·CH3SO3. It is synthesized via advanced organic coupling processes to inhibit BCR-ABL tyrosine kinase, serving as a cornerstone in oncology manufacturing.
Application
- Treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).
- Management of gastrointestinal stromal tumors (GIST) resistant to standard therapies.
- Research applications for studying signal transduction pathways in pharmaceutical R&D.
Precautions
Requires strict adherence to clinical dosing protocols to mitigate hepatotoxicity risks. Store in sealed containers at controlled room temperature away from moisture and direct light. Personnel must utilize appropriate PPE during handling to prevent dermal exposure.