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Overview
Imiglucerase is a recombinant human glucocerebrosidase enzyme used for treating Gaucher disease. Produced via Chinese Hamster Ovary (CHO) cell culture, its molecular formula is C2546H3980N668O781S28 with CAS No. 151479-29-1.
Application
- Hematology: Management of Type 1, 2, and 3 Gaucher disease to reduce organomegaly.
- Pediatrics: Treatment of infants and children with symptomatic visceral involvement.
- Orthopedics: Prevention of bone crises and improvement of bone mineral density.
Precautions
Contraindicated in patients with hypersensitivity to imiglucerase or mannose. Store unopened vials at 2°C to 8°C; do not freeze. Monitor for infusion-related reactions and anaphylaxis during administration.