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Overview
Isavuconazole is a broad-spectrum triazole antifungal agent synthesized via advanced heterocyclic chemistry. It functions as a prodrug converted to its active form, ISAVU, inhibiting 14α-demethylase. Molecular formula: C25H26N6O3; CAS No.: 189687-22-9.
Application
- Invasive Aspergillosis and Mucormycosis treatment in immunocompromised patients.
- Prophylaxis for high-risk hematologic malignancy recipients.
- Alternative therapy for azole-resistant fungal strains.
Precautions
Contraindicated with drugs metabolized by CYP3A4; requires hepatic function monitoring. Store below 25°C in dry conditions away from light. Strict adherence to dosage protocols is mandatory to avoid QT prolongation risks.