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Overview
Lapatinib is a small-molecule tyrosine kinase inhibitor targeting EGFR and HER2. Its molecular formula is C29H26ClFN4O3 with CAS number 231277-92-2. Core synthesis involves multi-step organic coupling under strict GMP conditions.
Application
- Oncology: Treatment of HER2-positive metastatic breast cancer in combination with capecitabine.
- R&D: Used as a reference standard for pharmacological assays and drug interaction studies.
- Manufacturing: Sourced by API producers for formulation into oral tablets.
Precautions
Contraindicated in severe hepatic impairment; requires monitoring of cardiac function. Store in sealed containers at 2°C–8°C, protected from light and moisture to maintain chemical stability.