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Overview
Lapatinib ditosylate is a small-molecule tyrosine kinase inhibitor used in oncology. It acts as a reversible dual inhibitor of EGFR and HER2. Molecular Formula: C30H31ClFN3O6S2. CAS No: 388082-77-3. Synthesis involves coupling lapatinib base with p-toluenesulfonic acid.
Application
- Oncology Manufacturing: Production of oral tablets for metastatic breast cancer therapy.
- Pharmaceutical R&D: Reference standard for bioequivalence studies and stability testing.
- Contract Manufacturing: API supply for generic drug developers targeting HER2-positive tumors.
Precautions
Contraindicated in patients with severe hepatic impairment. Store under inert atmosphere at controlled room temperature (20-25°C). Personnel must utilize PPE to prevent inhalation or dermal exposure during handling.