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Overview
LDK378 Dihydrochloride is a potent, orally bioavailable small-molecule inhibitor of the PI3K/AKT/mTOR pathway, developed for oncology. Its core synthesis involves chiral resolution and hydrochloride salt formation to enhance stability. Molecular Formula: C26H31ClN4O5S; CAS No.: 1940248-66-3.
Application
- Oncology: Clinical trials for solid tumors with PIK3CA mutations.
- Pharmaceutical R&D: Reference standard for kinase inhibition assays.
- Biochemical Research: Tool compound for studying mTOR signaling pathways.
Precautions
Strictly for research use only; not approved for clinical therapy. Store under inert atmosphere at -20°C. Personnel must wear PPE due to potential mutagenicity and respiratory irritation risks.