Leuprorelin/Leuprolideacetate (LA) is a highly active analogue (LHRH-A, GnRHA) of luteinizing hormone releasing hormone (LHRH, or gonadotropin releasing hormone, GnRH) produced by the hypothalamus
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Overview
Leuprorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) produced via solid-phase peptide synthesis. Its molecular formula is C59H84N16O12, with CAS number 57773-63-0.
Application
- Oncology: Management of advanced prostate cancer and central precocious puberty.
- Gynecology: Treatment of endometriosis, uterine fibroids, and assisted reproductive technology protocols.
- Research: In vitro studies on hormonal regulation mechanisms.
Precautions
Strictly contraindicated during pregnancy; requires monitoring for bone density loss. Store lyophilized powder below -20°C in a dry, dark environment to maintain stability.