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Overview
Levofloxacin cyclic ester refers to a specialized prodrug derivative of levofloxacin, designed to enhance lipophilicity and oral bioavailability. Synthesized via esterification with specific cyclic acid anhydrides or lactones, this intermediate is critical for advanced pharmaceutical formulations. Molecular Formula: C18H20FN3O4 (typical lactone variant); CAS No.: 180925-79-7.
Application
- Pharmaceutical manufacturing: Core intermediate for sustained-release oral tablets targeting respiratory infections.
- Drug delivery systems: Utilized in lipid-based nano-carriers to improve tissue penetration.
- R&D sector: Employed as a reference standard for metabolic stability studies.
Precautions
Strictly controlled due to potential QT prolongation risks; requires sterile processing environments. Store below -20°C in desiccated conditions to prevent hydrolysis. Handling mandates PPE to avoid skin absorption and inhalation of dust particles.