Linear monofunctional PEG derivatives have a reactive group at one end of the PEG and the other end is capped with a methoxy group or a sugar group.
where X is the functional group or active group and CAP can be either a methoxy group or a sugar molecule.
Linear monofunctional PEG derivatives are polyethylene glycol chains terminated with a single reactive group. Synthesized via ring-opening polymerization of ethylene oxide followed by end-capping, these compounds feature the general formula H-(OCH2CH2)n-X. Common variants include methoxy-PEG-OH (CAS 25930-18-7) and amino-PEG-COOH (CAS 65174-39-2), serving as critical intermediates for bioconjugation.
Store in sealed containers at -20°C to prevent hydrolysis. Avoid inhalation of dust; use appropriate PPE. Clinical applications require strict purity verification to minimize immunogenicity risks.