Lithospermum root P.E.
(Gromwells P.E.)
Botanical Source: Lithospermum erythrorhizon
Used Part: Root
Specification: Shikonin>30%
Appearance: Dark purple powder
Test Method: HPLC
Bulk density: 0.35-0.75g/mL
Moisture: <5%
Ash: <5%
Description:
Lithospermum is a genus of plants belonging to the family Boraginaceae. The genus is distributed nearly worldwide, but most are native to the Americas and the center of diversity is in the southwestern United States and Mexico.[1] Species are known generally as gromwells or stoneseeds. The active ingredient is shikonin.
Shikonin(Alkannin) is also found in the Chinese herbal medicine plant Lithospermum erythrorhizon, the red-root gromwell, (紫草 zicao, Pinyin: zǐcǎo). The dried root is a Chinese herbal medicine with various antiviral and biological activities, including inhibition of human immunodeficiency virus type 1 (HIV-1).
Function:
1. with antimicrobial effect against Staphylococcus aureus and Staphylococcus epidermidis.
2. wound healing, antitumor, and antithrombotic properties.
3. antioxidant.
Application:
Pharnaceutical, cosmetics, food addtive etc
*The following content is generated by AI and is for reference only.
Overview
Lithospermum root P.E. is a standardized extract derived from Gromwell (Lithospermum erythrorhizon) via ethanol or water extraction and concentration. It primarily contains shikonin derivatives, with typical CAS numbers including 517-89-7. The molecular formula for the active pigment is C17H16O5.
Application
- Dermatology: Used in topical formulations for wound healing and anti-inflammatory treatments.
- Pharmaceuticals: Sourced as an active ingredient for traditional Chinese medicine preparations.
- Natural Pigments: Utilized in cosmetics for natural red dye properties due to high color strength.
Precautions
Store in a cool, dry place away from direct sunlight to prevent degradation of active compounds. Ensure proper ventilation during handling to avoid dust inhalation. Clinical use requires strict dosage control due to potential hepatotoxicity associated with high concentrations of shikonin.