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Overview
Lopinavir is a potent HIV-1 protease inhibitor utilized in antiretroviral therapy. Manufactured via advanced asymmetric synthesis, its molecular formula is C57H74N10O8 (CAS: 192725-17-0). It is exclusively marketed as a fixed-dose combination with ritonavir to enhance pharmacokinetic profiles.
Application
- Pharmaceutical Manufacturing: Production of commercial HIV treatment tablets.
- Clinical Research: Investigational use in combination therapies for drug-resistant strains.
- Virology Studies: Mechanism analysis of viral replication inhibition.
Precautions
Strictly contraindicated for monotherapy due to rapid resistance development. Requires storage below 30°C in dry conditions. Personnel must utilize respiratory protection and chemical-resistant gloves during handling to prevent dermal absorption and inhalation risks.