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Overview
Losartan is a non-peptide angiotensin II receptor antagonist (ARB) used primarily for hypertension management. Synthesized via chemical coupling of biphenyl and imidazole derivatives, its molecular formula is C22H21ClN6 (CAS: 114798-26-4).
Application
- Pharmaceutical Manufacturing: Active Pharmaceutical Ingredient (API) production for antihypertensive tablets.
- Cardiovascular Therapy: Treatment of diabetic nephropathy and heart failure in clinical settings.
- Research & Development: Standard reference material for cardiovascular pharmacology studies.
Precautions
Contraindicated in pregnancy due to fetal toxicity risks. Store API in sealed containers below 25°C with low humidity control to prevent hydrolysis. Handle with appropriate PPE to avoid inhalation or skin contact during processing.