Category:
Amino Acids and Derivatives
CAS NO:
159857-81-5
Standard:
In-houseStandards,
Mc-Val-Cit-PAB-PNP is a cleavable linker used in antibody-drug conjugates (ADCs). It features a valine-citrulline dipeptide sequence recognized by cathepsin B, releasing the payload via self-immolative PAB spacer. The para-nitrophenyl (PNP) moiety serves as a leaving group for efficient conjugation.
Handle with strict safety protocols; avoid skin contact and inhalation due to potential toxicity. Store under inert atmosphere at -20°C to maintain stability and prevent hydrolysis or premature degradation.