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Overview
Methyl L-prolinate hydrochloride (CAS: 2133-40-6) is a chiral building block defined by the formula C7H13NO2·HCl. Produced via esterification of L-proline followed by acid treatment, it serves as a critical precursor for pharmaceutical synthesis.
Application
- Peptide Chemistry: Essential component in solid-phase peptide synthesis for constructing complex therapeutic sequences.
- Drug Development: Used as a scaffold in the manufacturing of angiotensin-converting enzyme (ACE) inhibitors and antiviral agents.
- Asymmetric Catalysis: Acts as a ligand or auxiliary in enantioselective reactions to ensure high optical purity.
Precautions
- Safety: Handle with gloves in a fume hood; irritant to skin and eyes.
- Storage: Store under inert atmosphere at 2-8°C to prevent hydrolysis.
- Regulatory: Not approved for direct clinical use; strictly for industrial R&D and API production.