Category:
Active Pharmaceutical Ingredients
CAS NO:
474645-27-7
Standard:
in house,
MMAE (Methionine-Valine-Citrulline-Monomethyl Auristatin E) is a potent cytotoxic agent derived from dolastatin 10. Synthesized via solid-phase peptide synthesis, it serves as the payload in Antibody-Drug Conjugates (ADCs). Its molecular formula is C28H46N4O5 with CAS No. 205927-10-2.
Strictly handled as a highly potent cytotoxin requiring specialized containment. Storage must be at -20°C under inert atmosphere. Direct exposure poses severe risks to personnel, necessitating full PPE and engineering controls during manufacturing.