Category:
Chiral Intermediates
CAS NO:
/
Standard:
In-house Standards,
/
MMAE (Methyl-auristatin E) is a potent cytotoxic agent derived from dolastatin 10, widely used as the warhead in Antibody-Drug Conjugates (ADCs). Its molecular formula is C29H45N7O6, with CAS No. 191384-53-5. The compound functions by binding to tubulin and inhibiting microtubule polymerization.
Strictly handled under GMP conditions due to extreme potency. Requires specialized containment (PPE/ventilation) to prevent inhalation or skin contact. Storage must be at -20°C in desiccated, light-resistant environments.