Category:
Chiral Intermediates
CAS NO:
1421373-65-0
Standard:
Ph. Int,
N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{4-(1-methylindol-3-yl)pyrimidin-2-yl}amino}phenyl)prop-2enamide (AZD9291 free base)
This compound is a potent kinase inhibitor scaffold, specifically targeting Bcr-Abl. Synthesized via nucleophilic aromatic substitution and amide coupling, its molecular formula is C28H35N7O. CAS No: 641570-89-8.
Requires storage under inert atmosphere at -20°C. Handle with PPE due to potential cytotoxicity; not approved for clinical use in current formulations.