Products

Suppliers

News

All Categories

Products or Suppliers

Content Hub

Product Zone

Sponsorship & Membership

CPHI & PMEC China

Active Pharmaceutical Ingredients Intermediates&Fine Chemicals Bio Products Natural Extracts Finished Dosage Pharmaceutical Excipients Pharmaceutical Outsourcing, Customised Services, and Consulting Medical Aesthetic Skincare Food Ingredients API Equipment Preparation Equipment Pharmaceutical Packaging Machinery TCM Machinery Pharmaceutical water equipment Clean Technology Refrigeration Equipment Parts and Components Informatization Products Laboratory Packaging Materials Measuring Instrument Environmental Protection Equipment Logistics Other Consumables Dietary Supplements‌‌

Correctives Colorant Filtration separation Intelligent Logistics Cold chain Technical &Materials Logistics Equipment &Materials Storage Equipment &Materials Logistic Services Third-party logistics Dangerous Goods Logistics Level instrument Pressure gauge Thermometers Flow meter Gas analysis instrument Liquid analysis instrument Fermenter Equipment Other Measuring Instrument Other Logistics Medical Aesthetic Consumables Sera and Vaccines Soft tube/Hard tube Pharmaceutical Intermediates Anti-tumor Preparations Pharmaceutical Manufacturing Outsourcing Chemical and Biochemical Reactors Mixing Equipment CIP System(Clean in place) Herbal medicine Concentration Equipment Purification Equipment Low Temperature Refrigeration Seals Laboratory General Equipment Functional Food Raw Materials Inner packaging equipment Polluted Water / Wastewater Treatment Equipment Injection Raw Materials and Ingredients IVD (In Vitro Diagnostics) Consumables Suspending Agents / Thickening Agents Concentrator Equipment MES System APIs for Anti-Infective Drugs Biochemical APIs Botanical products Pharma Packaging Materials Diluents (Fillers) Intermediates for Agrochemicals Reagent Cardiovascular, Cerebrovascular, and Circulatory System Formulations Pharmaceutical R&D Outsourcing Drying Equipment TCM Pulverizer Water Purification Equipment Purification Test Instrument Air Conditioner ‌Sanitary Fittings Analytical Instrument Other Dipstick Consumables Nutraceutical Ingredients Granules Machinery Outer packaging Waste Gas Treatment Equipment Active Ingredients Binders Solubilizers Drug delivery systems Sensors APIs for Nervous System Drugs Animal-derived products Endocrine and Metabolic Preparations Disintegrants service Crystalling Equipment Pill Making Equipment Other Water Treatment Equipment Clean Clothes/Clean Cap/Clean Shoes Cold Storage Pumps Food & Beverage Raw Materials Life Science Instrument Tablet equipment Other pharmaceutical packaging equipment Solid and Hazardous Waste Treatment Equipment Innovative Materials Controllers & Drivers Speciality Intermediates Microbial products Humectants APIs for Digestive System Drugs APIs for Cardiovascular System Drugs Antibacterial and Antiviral Formulations Lubricants Extraction Plant Slice Machine Clean Bench ‌Refrigeration Auxiliaries Valves Biologics TCM Raw Materials Food Additive Reagents and Consumables Capsule equipment Pharmaceutical water equipment Testing & Monitoring Instruments and Equipment Other Medical Aesthetics & Skincare Veterinary Pharmaceutical Intermediates Automation Software APIs for Respiratory System Drugs Bio Technology Service Antipyretic and Analgesic Preparations Glidants / Anti-caking Agents Heat Exchanger Herbal medicine Drying Equipment Air Shower Room Compressor Cylinders Fine Chemicals Crushing equipment Ultrapure Water System Other Automation & Informatization Products OEM/ODM Measuring Instruments Energy-saving and Low-carbon Equipment Other Intermediates Antiparasitic Preparations Coating Agents Storage Tanks, Containers Herbal medicine Extraction Equipment Air Purification Other Refrigeration Equipment Drive Equipment‌ Liquid preparation equipment Solution Preparation System Other Environmental Protection Equipment APIs for Hormones and Regulatory Drugs Other Natural Products Physical Testing APIs for Antiparasitic Drugs Anti-Allergic Formulations Plasticizer Evaporating Equipment TCM Cooking Equipments Cleanroom Reducers Laboratory Engineering Biopharmaceutical Equipment Membrane Module‌ APIs for Antipyretic and Analgesic Drugs Anti-Tuberculosis and Anti-Leprosy Formulations Surfactant Distillation Equipment Drop Pill Equipment Purifying Engineering VFD (Variable Frequency Drive) Other preparation equipment Distilled water machine Laboratory Solutions Vitamin Digestive System Preparations Centrifuge Screening Machine Honey Pill Machine Flooring Materials Bearing Emulsifiers Ion-exchange equipment Online Process Control Respiratory System Preparations Sterilizing Equipment TCM Deposition Equipment Spare Part‌ Other Cleaning System Stainless Steel Nervous System Preparations Filter press equipment Herbal medicine Fermentation Equipment Plastic ‌Containment System Special Active Ingredients Ointment Bases Homogenizer Equipment Other TCM Machinery Others Parts and Components APIs for Veterinary Drugs and Feed Additives Anaesthetic and Adjuvant Formulations Air Filter Suppository Bases Other Active Pharmaceutical Ingredients Blood System Formulations Cleanroom Consumables‌ Glass lining equipment Film-forming Agents Urinary and Reproductive System Formulations Other API Machinery and Equipment Filter Paper Release Modifiers Immunomodulatory Formulations Filter Paper Board smotic Pressure Regulators / Tonicity Adjusting Agents Water, Electrolyte, and Acid-Base Balance Regulating Formulations Ph Control Agents Nozzle, Tank Cleaning Machine Vitamin, Mineral, and Amino Acid Formulations Antioxidants / Antioxidant Synergists Fluid Equipment Enzyme and Other Biochemical Formulations Antimicrobial Preservatives (Preservatives) Tonic and Nutritional Formulations Complexing Agents (Chelating Agents / Inclusion Compounds) Hormonal Formulations Dermatological Preparations Other Preparations Co-solvents ENT Preparations Penetration Enhancers (Transdermal) Freeze-drying Protective Agents Refrigerants / Cryogens Capsule Fragrances Adsorbents Pressure-sensitive Adhesives (PSA) Stiffening Agents Carriers for Dry Powder Inhalers (DPI Carriers) Other Excipients

Pipes and Pipe Fittings Vacuum Equipment Air Compressor Compressor Other Fluid Equipment Prefillable Syringes Filters Filter Presstem Filtration System Filter Bag Filter Mesh Filter Cloth Filter Membrane Other Filtration Equipment Sanitary Pressure Vessel‌ Hyaluronic Acid Collagen Botulinum Toxin Peptide Other Injection Raw Materials and Ingredients Ceramide Ectoin Niacinamide Asiaticoside Ergothioneine Chitosan Other Active Ingredients Chiral Intermediates Advanced Intermediates Microfiltration Ultrafiltration Auxiliary Equipment Separation equipment Metered Dose Inhalers Dry Powder Inhalers Penicillin Hormones Central Nervous System Drugs Reagents for Biopharmaceuticals Drug Target Discovery and Validation Plant Extracts Animal Extracts Synthesis/Screening Process Development/Optimisation/Scale-Up Production Drug Registration and Submission Services Ointment Filling-sealing Machine、Vacuum Mixer Eye Drug Machinery Soft Gelatin Capsule Machinery Tablet Press Pneumatic Cracker Granulator Labelers, Label Printers Bag Packaging Machine Thermostatic / Heating / Drying Equipment Chromatography Particle Size / Particle / Powder Analysis Instruments Tabletop Glass bottles & Vials Fermentation Products Prophylactic Biological Products Mixing Tank/Blender Bioreactor Intravenous Infusion Set Assembly Equipment(Pen Assembly Equipment) PCR Recombinant Collagen Alkaloids Veterinary API Regulated Fine Chemicals Peptides Balances / Weighing Scales Online Gas Chromatography Cephalosporins Anesthetics Immunology Reagents Drug Development Technologies Pharmaceutical Chemistry Formulation Design Regulatory and Compliance Consulting Syrup Machinery Injection Medicine Machinery Hard Capsule Filling Machine Coating Machine Medicine Material Grinding Machine Lettering machine Box Packaging Machine Mass Spectrometry Laboratory Bench Aluminum Foil Rheometers / Viscometers ‌Chemical Reagents Cleaning & Disinfection Equipment Granulator Emulsifier Biological Fermentation System Injection Molding Equipment Exosome Phospholipids Prostaglandins Veterinary Biologics Chemical Reagents Therapeutic Biological Products Biochemical Reagents Antibodies Natural Pigments Animal Lipids Enzyme Preparations Flowmeters Online Particle Size Analyzer Tetracycline Amino Acids and Derivatives Process Optimization and Testing Nucleic Acids and Derivatives Pre-Clinical Research Chemical/Biological API Manufacturing Powder Filling Machine Oral Liquid Machinery Low Temperature Pulverizer Strapping machine Paper Film Packaging Machine Thermal Analyzers Spectrometers Other Measurement and Metrology Instruments Storage Cabinets Plastic Bottles Other Industrial Process Control and Online Analytical Instruments Certification Feed Additives Diagnostic Biological Products Pulverizer Coating Machine Capsule Filling Machine Other Mixing Equipment Cell Engineering Equipment Pre-filled Syringe Production Equipment Purification Equipment Electrophoresis/Gel Imaging/UV Detection Regenerative Materials Other Fine Chemicals Cell Biology Reagents Biological Consumables Feed Additives Soft Mist Inhaler Plant Polysaccharides Animal Proteins Microbial Polysaccharides Aminoglycoside Enzymes Molecular Biology Reagents Clinical Trials Intermediate Synthesis and Production Market and Business Strategy Consulting Suppository Drug Machinery Powder Injection Machinery Pharmaceutical Milling Machinery Printing Device Blister Packaging Machine Environmental Test Chambers Moisture Analyzer Air Discharge Equipment Rubber Stopper Tablet Press Other Tablet Equipment Capsule Production Line Isolator Synthesis/Reaction Equipment Microbial Detection Instrument Composite Biomaterials Animal Breeding Auxiliary Products Packaging Testing Equipment Laboratory Glassware and General Consumables Preclinical Research Services Nebulizer Essential Oils Animal Polysaccharides Bioactive Functional Ingredients Macrolides Microbial / Fermentation Reagents Proteins Other Technology Services Biotechnology Services Formulation Development and Manufacturing Other Services Medicine Film Drug Machinery Infusion Medicine Machinery（中文站有输液剂机械的三级分类） Pharmaceutical Machine Milling Instruction Booklet Folding Machine Fan Chromatography Consumables and Accessories Other Physical Properties Testing Instruments Gasket Sample Preparation / Digestion Equipment X-ray Structure Analysis Safety Cabinet Counting Machine (Tablet) Other Capsule Filling Equipment Disposable Biotechnology Equipment Vacuum Packaging Machine Laboratory Low-temperature Storage Other Innovative Materials Other Veterinary Conveying equipment Natural Spices Bile Acids and Active Ingredients Sulfonamides Other Specialized Reagents Computational Chemistry and AI-Assisted Drug Design Clinical Trial Drug Manufacturing Aerosol Drug Machinery Super Micro Mill Bottle Conveyer Bundling Packaging Machine Mixing/Dispersion Equipment Other Laboratory Complete & Ancillary Equipment Trays Other Laboratory Consumable Other Preparation Machinery for Solid Medcine ‌Centrifugal Separation System Automatic Packaging Machine Other Analytical Instrument Chip System/Accessories Cytokines Counting Machine Cartridge Vial Medicinal Herbs Bee Products Chloramphenicols Testing Other Pharmaceutical Manufacturing Outsourcing Medicine Filling Machine Disk Type Bottle Straightening Machine Lidding Materials Other Crushing Equipment Ultrafiltration/Microfiltration System Horizontal Pillow Packaging Machine Cartoning Machine Auto-injector Transfection/Cell Fusion Track & Trace Gas Generators / Gas Handling Equipment Blood Products TCM Ingredients & Slices Animal Medicinal Materials Lincomycin Microbial Products Bottle Washer Vial Sealing Machine Liquid Handling Equipment Hoses and Fittings Other Biopharmaceutical Equipment Vertical Packaging Machine Casing Machine Microplate Reader/Enzyme Labeling Instrument Analysis and Validation Serialization System Pen Injector Other Anti-Infective Drug Other Pharmaceutical R&D Outsourcing Conveyer For Medicine Material Spray Pump Other Injectable Equipment Aluminum Foil Packaging Machine Coding Machine Cell Analysis Automated Assembly Other Laboratory General Equipment Packaging Bag Valve Freeze Dryer Granule packaging machine Other Drug Delivery Device Accessories Biological Microscope/In Vivo Imaging Other Antibiotics Cap Screwing Machine Nasal Drug Delivery Devices / Nasal Spray Pumps Printing Services‌ Liquid Packaging Machine Laboratory Automation Screw Capping Machine Lamp Inspection Machine Ophthalmic Drug Delivery Devices / Eye Drop Delivery Systems Labelling Powder Packaging Machine Synthesizer Heat Shrink Packaging Machine Metal Detector Insulin Pens / Blood Glucose Management Devices Security Taggants & Markings Filter Cartridge‌ Tablet Packaging Machine Animal Experiment Instrument Injection & blow molding machines Batching system Self-Injection Systems / Safety Protection Devices Incubator Equipment Printed Drugs Packaging Box filling & sealing machine Palletizing equipment CIP cleaning system Topical / Gynecological / Intimate Drug Delivery Devices Desiccants Other Life Science Instrument Bottle Filling Line Contaners Lifting Charging Machine Others Inhalant Packaging BFS Bottlepack Machine Weighting Equipment Blister Packaging Machine Pharmaceutical Paper Other Pharmaceutical Outer Packaging Equipment Packaging bag valve Container Sealing Machine Glass Tube Multi-functional Bottle Packaging Machine Medical Aesthetic Freeze-Dried Powder Vials Sachets Cartoner Packing line Primary Packaging Other Pharmaceutical Inner Packaging Equipment Aluminum Caps & Aluminum-Plastic Combination Caps Sterile Bags / Breathing Bags / Sterilization Bags Medical Device Packaging / Bioconsumables Packaging Dispensing Bottles Blister Packaging Pharmaceutical Plastic Films / Composite Film Bags Accessories Ampuls Other Packaging Materials

Products Suppliers Match & Meet

Industry Insights E-Learn Series Pharma Sources Insight

E-trade Season PharmaExpress

Service & Membership Contact Us

CPHI China PMEC China CPHI & PMEC Shenzhen

Home Products Natural Extracts

Natamycin Powder

Category:

Natural Extracts

Standard:

In-house Standards,

Price Range:

Get Quote

Main Sales Markets:

North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

Send inquiry

Shaanxi Yuantai Biological Technology Co., Ltd

Years

Show Room

Favorites

Basic Info

Pharmacopoeia

In-house Standards

Grade

Food Grade

Is Manufacturer

YES

Product Description

What Is Natamycin Powder?

Natamycin powder is an organic compound, a natural antifungal compound produced by Streptomyces fermentation, belonging to polyene macrolides, which can widely and effectively inhibit the growth of various molds and yeasts, and It can inhibit the production of mycotoxins, and can be widely used in food preservation and antifungal treatment.
Natamycin was first isolated from Streptomyces natalis in 1955, and its activity is far superior to that of sorbic acid. In June 1982, the U.S. FDA officially approved natamycin as a food preservative and classified it as a GRAS product. Natamycin is a highly effective inhibitor of mold, yeast and fungi. It is used to inhibit mold, yeast and fungi in food. It is very safe and reliable for the human body without affecting the flavor of the product. It is widely used in the world. For cheese, meat products, pastries, fruit juice and other foods. The product is refined from streptomyces natalensis through submerged fermentation and multi-step extraction process, and its preparation is made by mixing 50% natamycin and 50% lactose.
Natamycin has a strong inhibitory effect on mold, yeast and fungus, but has no inhibitory effect on other microorganisms such as bacteria and viruses. Natamycin has a certain ability to resist heat treatment, is relatively stable in a dry state, and can withstand short-term high temperatures (100°C); but because it has a ring chemical structure and is sensitive to ultraviolet rays, it should not be exposed to sunlight. The anchor point stability of natamycin activity is affected by pH value, temperature, light intensity, oxidants and heavy metals, so the product should avoid contact with oxides and sulfhydryl compounds.

YTBIO with customers in application of implementing Natamycin, both in situ or at lab scale. We deliver Natamycin with bothLactose, Glycose or Sodium chloride or simply pure as per customers requirement.

Product Details Form

CAS	7681-93-8
Molecular formula	C33H47NO13
Molecular weight	665.73
EINECS	231-683-5
Boiling point	952.2 ℃
Water solubility	almost insoluble
Melting point	2000C (dec)
Density	1.0 g/mL at 20 °C(lit.)
Solubility	Soluble in DMSO
Acidity coefficient (pKa)	pKa 4.6 (50% aq. MeOEtOH) (Uncertain); 8.35 (Uncertain)

Key Benefits

1.Natamycin is an antimycotic ingredient with a broad anti-fungal activity against various moulds and yeasts. It also inhibits the formation of fungal toxins. Natamycin does not inhibit the growth of bacteria therefore it does not affect the natural fermentation of yoghurt, cheese, raw ham, dry sausage, etc.

2.The sclubility of natamycin is very low in water and in most organic solvents. This low solubility makes it very suitable for use on the surfaces of food. 3.Natamycin will stay on surface of the food, where most moulds and yeasts may grow.

Natamycin is effective at pH 3-9, making it suitable for acidic, neutral and alkaline foods.

Antibacterial Mechanism

Natamycin powder relies on its lactone ring structure to interact with sterol compounds on the fungal cell membrane to form antibiotic-sterol compounds, thereby destroying the structure of the fungal cytoplasmic membrane. The hydrophilic part (polyol part) of the macrolide forms water holes on the membrane, which damages the permeability of the cell membrane, which in turn causes the leakage of amino acids, electrolytes and other substances in the bacteria, and the bacteria die. When there is no sterol compound on the cell membrane of certain microorganisms, natamycin has no effect on it, so natamycin only inhibits fungi, and has no antibacterial activity against bacteria and viruses.

*Note: Indicative Usage Level To Inhibit The Growth Of Fungi

Microorganism	MIC (mg/kg)
Aspergillus flavus	5
Aspergillus niger	2
Aspergillus oryzae	10
Penicillium	2.5
Candida albicans	2
Brettanomyces	1.5
Saccharomyces cerevisic	2.5

Application Direction

Food Use

Natamycin is a natural, broad-spectrum, efficient and safe inhibitor of filamentous fungi such as yeast and mold. It can not only inhibit fungi, but also prevent the production of mycotoxins. Natamycin is harmless to the human body, it is difficult to be absorbed by the human digestive tract, and it is difficult for microorganisms to develop resistance to it. At the same time, because of its low solubility, it is usually used for surface preservation of food. biological preservatives.

The European Union has approved it to be used in the field of cheese and meat products, and the Netherlands has also approved natamycin for the preservation of apples and pears. US FDA approves natamycin as a food preservative and allows natamycin to be used on cheese. Countries in the Middle East allow natamycin to be used as a preservative in all foods. Brazil, Argentina and other Latin American countries allow natamycin to be used in cheese and meat products. Since 1997, the Ministry of Health of my country has officially approved natamycin as a food preservative, and has been approved for use in cheese, sauced meat products, smoked and barbecued meat, fried meat, Western-style ham, meat enemas, and fermented meat products Surfaces of vegetables, pastries, juice purees, and mold-prone food processing vessels, and added to fermented wine, mayonnaise, and salad dressings. The US FDA has approved the addition of 11ppm natamycin to feed to improve feed mildew. In 2000, Wyatt et al studied the application of natamycin in feed. They inserted 191 strains of Aspergillus that may be contaminated in feed into gradient plates containing natamycin, and found that the minimum lethal dose (MIC) of various Aspergillus was below 0.4g/L.

Application Examples

1.Spraying a natanycin solution of 300mg/L in an aqueous solution on the surface of the cake can protect it from the mould growth and extend its shelf life.
2.Dipping the sausage in 300mg/L natamycin aqueous suspension can prevent it from mould growth and slime or sticky surface development.
3.Adding 5-10mg/kg of natamycin in wine, fruit and vegetable juices can prevent them from spoilage and extend their shelf life.
4.Spraying natamycin suspension of 300mg/L in an aqueous solution on the surface of cheese can prevent the cheese from mould growth and extend its shelf life.

Natamycin

Medical Use

Natamycin is used to treat fungal infections, including Candida, Aspergillus, Fusarium, etc. It is also used as eye drops or oral medicines. In these applications, the body absorbs less natamycin. When taken orally, there is little absorption from the gastrointestinal tract, thus making it unsuitable as a systemic infectious agent. Natamycin is also used in eye drops, and its 5% natamycin content is suitable for the treatment of fungal blepharitis, conjunctivitis and keratitis caused by microorganisms, including Fusarium solani keratitis.

Natamycin powder

Natamycin Powder Range Of Use

GB 2760-2014 "Guidelines for the Use of Food Additives in National Food Safety Standards" stipulates that natamycin can be used in cheese and processed cheese and its analogues, pastries, sauced meat products, smoked barbecue meat, fried meat , Western-style ham, meat enema, fermented meat products, mayonnaise and salad dressing, fruit and vegetable juice (pulp) and fermented wine 11 types of food.

Natamycin should not be used in other foods other than the above food categories. It should be noted that in the food classification of GB 2760-2014, pastry and bread are two types of products. That is to say, natamycin cannot be used as a preservative on bread. And if natamycin is added during the bread making process, it will inhibit the fermentation of the yeast and cause the bread not to rise.

Safety

Natamycin powder is harmless to the human body, it is difficult to be absorbed by the human digestive tract, and it is difficult for microorganisms to develop resistance to it. The US FDA recommends that natamycin be used as an antibiotic for food additives, and it is also classified as a GRAS product. In 1996, my country's Food Additives Committee evaluated natamycin and suggested its use, and it has now been included in the standards for use of food additives. American CFR code: 21CFR172.155, in which the DAI value of natamycin is 0.3mg/kg, according to my country's "food additive use health standard" (GB2760), the maximum residue in food is 10mg/kg, and natamycin The amount of mycin used in practical applications is on the order of 10-6.

Company Introduction And Certificates Obtained

Shaanxi Yuantai Biotechnology Co., Ltd. was established in 2014, mainly supplying herbal extracts, functional cosmetic raw materials, organic products, etc. We have our own factories, R&D and quality inspection teams, and have the conditions for development, production, and quality assurance. At present, we have obtained ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA and other certificates. Therefore, the quality of our products is guaranteed, and it is our original intention to bring high-quality products to customers.

product-750-450

Our Packaging

product-750-610