Category:
Preclinical Research Services
CAS NO:
105746-45-0
Standard:
ChP,
Nateglinide is a rapid-acting meglitinide derivative used to manage postprandial hyperglycemia in type 2 diabetes. It acts by stimulating insulin secretion from pancreatic beta cells via ATP-sensitive potassium channels. The standard pharmaceutical synthesis involves condensation reactions yielding the active ingredient with molecular formula C20H27NO4 and CAS No. 154661-86-2.
Strictly contraindicated in type 1 diabetes or diabetic ketoacidosis. Requires careful monitoring of blood glucose to prevent hypoglycemia, especially in elderly patients. Store API in sealed containers at controlled room temperature away from moisture and direct light.