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Overview
Nelarabine is a prodrug of the purine nucleoside analog 9-β-D-arabinofuranosylguanine (ara-G), utilized in oncology. Its core synthesis involves enzymatic conversion to ara-G for DNA incorporation. The molecular formula is C10H13N5O4, with CAS number 126851-09-6.
Application
- Hematologic Malignancies: Treatment of relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma.
- Clinical Trials: Investigated for combination therapies in resistant leukemias.
- Pharmaceutical Manufacturing: Sourced as active pharmaceutical ingredient (API) for injectable formulations.
Precautions
Strictly indicated for patients who have failed prior chemotherapy. Requires monitoring for neurotoxicity, myelosuppression, and tumor lysis syndrome. Store at controlled room temperature (20°C–25°C) in original containers protected from light and moisture.