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Overview
Nelarabine is a prodrug of the purine nucleoside analog 9-β-D-arabinofuranosylguanine (ara-G). It undergoes enzymatic conversion to ara-G for selective incorporation into DNA, inhibiting replication in T-cell malignancies. Molecular Formula: C10H13N5O4; CAS No.: 126470-80-8.
Application
- Treatment of relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL).
- Management of T-cell lymphoblastic lymphoma (T-LBL) in pediatric and adult populations.
Precautions
Contraindicated in patients with prior hypersensitivity. Requires strict monitoring for neurotoxicity and myelosuppression. Store at controlled room temperature (20°C to 25°C) in original packaging protected from light.