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Overview
Nilotinib is a second-generation Bcr-Abl tyrosine kinase inhibitor used in oncology. It is synthesized via multi-step organic reactions involving specific heterocyclic intermediates. Its molecular formula is C27H31N5O with CAS No. 64157-92-6.
Application
- Oncology Manufacturing: Production of pharmaceutical APIs for chronic myeloid leukemia (CML) treatment.
- Research & Development: Supply to laboratories for kinase inhibition studies and drug discovery programs.
- Distribution: Bulk supply to generic manufacturers and contract development organizations.
Precautions
Strictly controlled due to QT prolongation risks; requires GMP-compliant storage at 2-8°C. Handling mandates PPE to prevent inhalation or skin contact during industrial processing.