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Overview
Nintedanib Esylate is the esylate salt of nintedanib, a potent triple angiokinase inhibitor. Its molecular formula is C27H30N6O4S with CAS No. 1189665-87-3. Core synthesis involves esterification and salt formation to enhance stability.
Application
- Fibrotic lung diseases: Idiopathic Pulmonary Fibrosis (IPF) management.
- Non-small cell lung cancer: Combination therapy with docetaxel.
- Chronic fibrosing interstitial lung diseases: Slowing disease progression.
Precautions
Contraindicated in severe hepatic impairment. Monitor liver enzymes regularly. Store in tightly sealed containers at 2-8°C protected from light to maintain chemical integrity.