Category:
Chiral Intermediates
CAS NO:
656247-17-5
Standard:
In-house Standards,
COA,NMR,HPLC,MSDS, ROS,DMF all available. NLT 99.5% HPLC ,Individual impurity <0.5%
Nintedanib (INN), also known as Intedanib or Vargatef, is a small-molecule tyrosine kinase inhibitor. Its chemical formula is C25H24F2N6O2 with CAS No. 933178-09-3. The core synthesis involves multi-step organic reactions focusing on regioselective coupling to ensure high pharmaceutical purity for global supply chains.
Contraindicated in patients with severe hepatic impairment or hypersensitivity. Storage requires controlled conditions between 2°C and 8°C to maintain stability. Strict occupational safety protocols must be followed during handling to prevent inhalation exposure.