Category:
Intermediates&Fine Chemicals
CAS NO:
1161415-28-6
Standard:
In-house Standards,
NOTA-bis(t-Bu ester) is a protected macrocyclic chelator derived from 1,4,7-triazacyclononane-1,4,7-triacetic acid. It serves as a critical precursor in radiopharmaceutical synthesis, featuring tert-butyl esters to enhance lipophilicity during peptide conjugation. The compound enables efficient labeling with radionuclides like Gallium-68 or Copper-64. Its specific molecular formula and CAS number require verification against current supplier catalogs due to derivative variations.
Store under inert atmosphere at low temperatures to prevent hydrolysis of ester groups. Handle with standard laboratory PPE; avoid skin contact. Not approved for direct clinical administration without final radiolabeling and purification steps.