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Overview
Osimertinib mesylate (AZD9291) is a third-generation EGFR tyrosine kinase inhibitor. It features a specific synthesis route targeting T790M mutations. The chemical formula is C28H30N6O5·CH4O3S, with CAS number 1421616-75-2.
Application
- Pharmaceutical Manufacturing: Production of API for non-small cell lung cancer treatments.
- Clinical Research: Usage in Phase III trials for drug-resistant EGFR-mutant populations.
- Quality Control: Reference standard for HPLC and mass spectrometry calibration.
Precautions
Strictly controlled as a prescription-only pharmaceutical intermediate. Store below -20°C under inert atmosphere to maintain stability. Personnel must utilize appropriate PPE to prevent inhalation or dermal exposure during handling.