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Overview
Oxaliplatin is a third-generation platinum-based chemotherapeutic agent synthesized via coordination of oxalato ligands with diaminocyclohexane. Molecular Formula: C8H14N2O4Pt; CAS No.: 61825-94-3.
Application
- Adjuvant therapy for stage III colon cancer post-surgery.
- First-line treatment for metastatic colorectal carcinoma.
- Combination regimens with fluoropyrimidines in advanced GI malignancies.
Precautions
Contraindicated in patients with severe hypersensitivity to platinum compounds. Requires cold-chain storage at 2°C to 8°C to maintain stability. Strict PPE protocols are mandatory during handling due to potential neurotoxicity and sensitization risks.