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Overview
Paliperidone is the major active metabolite of risperidone, a second-generation antipsychotic. Produced via semi-synthesis from risperidone or direct synthesis, its molecular formula is C23H28FN4O5 with CAS No. 103639-00-9.
Application
- Schizophrenia management in acute and maintenance phases.
- Treatment of schizoaffective disorder episodes.
- Bipolar I disorder associated with manic or mixed episodes.
Precautions
Contraindicated in patients with hypersensitivity to risperidone or paliperidone. Store below 25°C in dry conditions away from light. Strict adherence to dosage protocols is required to mitigate risks of QT prolongation and metabolic syndrome.