Peficitinib is an oral JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.
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Overview
Peficitinib is a selective JAK inhibitor developed for rheumatoid arthritis. Its molecular formula is C26H28N4O and CAS number is 1279550-96-7.
Application
- Treatment of moderate to severe rheumatoid arthritis
- Targeting JAK1/3 pathways in autoimmune disorders
- Oral small-molecule therapeutic development
Precautions
Contraindicated in active infections; monitor liver function and lipid levels. Store in cool, dry conditions away from light.