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Overview
Pemetrexed Disodium Hemipentahydrate is a folate analog antimetabolite used in oncology. It inhibits thymidylate synthase and other enzymes essential for DNA synthesis. Molecular Formula: C20H22N6Na2O7S·2.5H2O; CAS No.: 149125-87-7.
Application
- Lung cancer treatment: Non-small cell lung cancer (NSCLC) maintenance or combination therapy.
- Oncology protocols: Malignant pleural mesothelioma management.
- Pharmaceutical manufacturing: API production for injectable formulations.
Precautions
Contraindicated in patients with severe renal impairment without dose adjustment. Requires folic acid and vitamin B12 supplementation to reduce toxicity. Store in controlled conditions below 25°C, protected from light and moisture.